Vision Research

Dr. Tan conducted Doctoral scientific studies at Moorfields Eye Hospital and the Institute of Ophthalmology at University College London in the UK where he developed techniques to automate and customize recognition of progressive glaucoma. He went on to perform postdoctoral research in glaucoma cell biology and physiology at the University of New South Wales in Sydney, Australia and University of Wisconsin. Then for a decade he directed a glaucoma basic research laboratory at the Doheny Eye Institute, USC and UCLA in Los Angeles, working on new ways to understand, diagnose and treat glaucoma. His more recent research has been performed with Sightgene, Inc in Northridge, CA. The lists below plot timelines, recognition and publications from these projects. The publications are descriptive milestones of our work that are available online or by contacting us for copies.

Awards

2017-2023 – National Eye Institute/National Institutes of Health, Award R01EY026935.
Principal Investigator “Fibrillin-1 and TGFβ2 abnormality models POAG pathogenesis and treatment”

2018-2022 – National Eye Institute/National Institutes of Health, Award R21EY029062. Principal Investigator “Contractile modulation of distal aqueous humor drainage”

2018 – LA Top Docs

2017 – Pasadena Top Docs

2016 – Pasadena Top Docs

2015 – Pasadena Top Docs

2015 – American Ophthalmological Society Travel Award

2015 – US Patent Office Patent #10117776 Inventor; “Devices and methods for treatment of ocular disorders through delivery of therapeutic nucleic acids”

2014 – Gerald Oppenheimer Family Foundation Center Award for the Prevention of Eye Disease. Principal Investigator (2014-2015) “In vivo electroporation-assisted gene delivery to the trabecular meshwork”


2014 – USC Roski Eye Institute Resident Teacher Award

2013- 2014 – American Glaucoma Society Award. Principal Investigator “Imaging Human Trabecular Meshwork Cell Biology and Pharmacology”

2013 – American Glaucoma Society Award. Principal Investigator “Two-photon Imaging Model of the Trabecular Meshwork”

2012 – Gordon Research Conference Carl Storm Award to Tan Laboratory

2011 – Association for Research in Vision and Ophthalmology Travel Award to Tan Laboratory

2011-2014 – Research to Prevent Blindness Career Development Award. Principal Investigator “Regulation of Aqueous Drainage Resistance by Trabecular Meshwork Contractility”

2010-2015 – National Eye Institute/National Institutes of Health, Award KO8EY020863-04.
Principal Investigator “Role of Trabecular Meshwork Contractility in Modulating Outflow Resistance”

2009 – University of Wisconsin Excellence in Ophthalmic Knowledge OKAP Award

2009-2018 – Karl Kirchgessner Foundation Award. Principal Investigator “Modeling Adhesion-based Mechanotransduction in the Trabecular Meshwork”

2008 – US Patent Office Patent #7410258 Inventor; “Method and Apparatus for Monitoring Glaucoma using Scanning Laser Tomography”

2005 – National Eye Institute/National Institutes of Health Award Co-Investigator (2005-2008) “Building an Artificial Trabecular Meshwork”

2005 – British Medical Association Best Medical Textbook of the Year: Atlas of Clinical Ophthalmology

2003 – New South Wales University Clinical School Postgraduate Research Award, Australia

2002 – International Glaucoma Association Research Award, London, UK

2001 – Association for Research in Vision and Ophthalmology Travel Award

2001 – Glaucoma Research Foundation/ARVO Travel Award

1999 – Committee of Vice Chancellors and Principals of the United Kingdom ORS Scholarship

1999 – University College London Postgraduate School Major Award, UK

1999 – Glaucoma Society of UK & Eire Optic Nerve Research Prize, UK

1998 – Moorfields Eye Hospital, London Frances & Renee Hock Trust Fellowship, UK

1995 – Allerton Trust Vision Research Fellowship, London, UK

1994 – University of Sydney Honors awarded with MBBS, Australia

1993 – University of Sydney Jan Coppleson Memorial Award in Cancer Medicine, Australia

1992 – University of Sydney Karitane Pediatric Prize, Australia

1989 – University of Sydney St Andrews College Merit Scholarship, Australia

1988 – Australian Commonwealth Merit Programme University of Sydney Medical School

PEER-REVIEWED PUBLICATIONS

Tan JCH, Jeffery HE. Factors that influence the choice of infant feeding. J Paediatr Child Health 1995;31:375-8

Tan JCH, Lai YK. Characteristics of diabetic retinopathy patients at initial presentation. Med J Malaysia 1996;51:188-92

Tan JCH, Spalton DJ, Arden GB. Glare testing and visual assessment in posterior capsular opacification. J Cataract Refract Surg 1998;24:1626-31

Tan JCH, Spalton DJ, Arden GB. The effect of Neodymium:YAG capsulotomy on contrast sensitivity and the evaluation of methods for its assessment. Ophthalmology 1999;106(4):703-9

Poinoosawmy D, Tan JCH, Membrey LW, Bunce C, Hitchings RA. Longitudinal change in retinal nerve fibre layer thickness in normal pressure glaucoma. Graefes Arch Clin Exp Ophthalmol 2000,238:965-969

Tanner V, Harle D, Tan J, Foote B, Williamson TH, Chignell AH. Acute posterior vitreous symptomatology. Br J Ophthalmol 2000,84:1264-8

Tan JCH, Byles D, Stanford M, Frith P, Graham EM. Acute retinal necrosis in children caused by herpes simplex virus. Retina 2001;21:344-7

Tan JCH. Capsulotomy. Curr Opin Ophthalmol 2001;12:82-5

Tan JCH, Hitchings RA. Non-penetrating glaucoma surgery: the state of play. Br J Ophthalmol 2001; 85:234-237

Hitchings RA, Tan JCH. Target pressure. J Glaucoma 2001;10:S68-70

Poinoosawmy P, Tan JCH, Bunce C, Hitchings RA. The ability of the GDx neural network to diagnose glaucoma. Graefes Arch Clin Exp Ophthalmol 2001,239:122-127

Tan JCH, Franks WA, Hitchings RA. Interpreting glaucoma progression by white-on- white perimetry. Graefes Arch Clin Exp Ophthalmol 2002;240:585-592

Tan JCH, Garway-Heath DF, Fitzke FW, Hitchings RA. Variability across regions of the optic nerve head in scanning laser tomography. Br J Ophthalmol 2003;87:557-9

Tan JCH, Garway-Heath DF, Hitchings RA. Reasons for rim area variability in scanning laser tomography. Invest Ophthalmol Vis Sci 2003;44:1126-31

Tan JCH, Hitchings RA. Reference plane definition and reproducibility in optic nerve head images. Invest Ophthalmol Vis Sci 2003;44:1132-7

Tan JCH, Hitchings RA. An approach for identifying glaucomatous optic nerve progression by scanning laser tomography. Invest Ophthalmol Vis Sci 2003;44: 2621-26

Tan JCH, Hitchings RA. Magnification changes in scanning laser tomography. J Glaucoma 2004;13(2):137-141

Tan JCH, Poinoosawmy D, White E, Hitchings RA. Validity of rim area measurements by different reference planes. J Glaucoma 2004 13(3):245-250

Tan JCH, Hitchings RA. Optimising and validating an approach for identifying glaucomatous change in optic nerve head topography. Invest Ophthalmol Vis Sci 2004 45:1396-1403

Tan JCH, Poinoosawmy D, Hitchings RA. Tomographic identification of neuroretinal rim loss in high-pressure glaucoma, normal-pressure glaucoma and glaucoma suspects. Invest Ophthalmol Vis Sci 2004 45: 2279-2285

Tan JCH, Hitchings RA. Reversal of disc cupping after IOP reduction in tomographic image series. J Glaucoma 2004 13:351-355

Kalapesi FB, Tan JC, Coroneo MT. Stretch-activated channels: a mini-review. Are stretch-activated channels an ocular barometer? Clin Experiment Ophthalmol. 2005 33:210-7

Tan JCH, Kalapesi F, Coroneo MT. Mechanosensitivity and the eye: cells coping with the pressure. Br J Ophthalmol. 2006;90:383-8

Tan JCH, Peters DP, Kaufman PL. Recent developments in understanding the pathophysiology of elevated intraocular pressure. Curr Opin Ophthalmol 2006;17:168-74

Tan JCH. Fison’s Retinal Detachment Surgery 3ed. Arch Ophthalmol 2007;125:1144

Tan JCH, Lucarelli MJ, Gentry L, Albert DM. Complex choristoma masquerading as a dacryocystocele. Arch Ophthalmol. 2009;127:823-826

Tan JC, Kiland JA, Gonzalez JM, Gabelt BT, Peters DM, Kaufman PL. Sodium orthovanadate effect on outflow facility and intraocular pressure in live monkeys. Exp Eye Res. 2010 Oct;91(4):486-90

Tan JC, Gonzalez JM Jr, Hamm-Alvarez S, Song J. In situ autofluorescence visualization of human trabecular meshwork structure. Invest Ophthalmol Vis Sci. 2012 Apr 24;53(4):2080-8

Gonzalez JM Jr, Heur M, Tan JC. Two-photon immunofluorescence characterization of the trabecular meshwork in situ. Invest Ophthalmol Vis Sci. 2012 Jun 5;53(7):3395-404.

Gonzalez JM Jr, Hamm-Alvarez S, Tan JC. Analyzing live cellularity in the human trabecular meshwork. Invest Ophthalmol Vis Sci. 2013, Feb 5;54(2):1039-47

Huang A, Gonzalez JM Jr, Heur JM, Tan JC. Sources of structural autofluorescence in the human trabecular meshwork. Invest Ophthalmol Vis Sci. 2013 Jul 18;54(7):4813-20

Chu ER, Kim EK, Gonzalez, JM Jr, Ko MH, Liew EC, Tan JC. Intraocular pressure measurement in acepromazine-sedated mice. Clin Experiment Ophthalmol. 2014,42,395- 397

Ko MK, Chu ER, Tan JCH. Smooth muscle features of mouse extraocular muscle. Clin Experiment Ophthalmol. 2014 Apr;42(3):295-6

Gonzalez JM Jr, Hsu HY, Tan JC. Observing live actin in the human trabecular meshwork. Clin Experiment Ophthalmol. 2014 Jul;42(5):502-4

Ko MK, Tan JCH. Contractile markers distinguish structures of mouse aqueous drainage tract. Mol Vis, 2013, Dec 16;19:2561-70

Gonzalez JM, Tan JCH. Semi-automated vitality analysis of human trabecular meshwork. IntraVital 2013, eLocation ID: e27390; http://dx.doi.org/10.4161/intv.27390

Chu ER, Gonzalez JM Jr, Tan JC. Tissue-based imaging model of human trabecular meshwork. J Ocul Pharmacol Ther. 2014 Mar-Apr;30(2-3):191-201. PubMed PMID: 24517246 (invited)

Ko M, Yelenskiy, A, Gonzalez JM, Jr, Tan JCH. Feedback-controlled constant pressure anterior chamber perfusion in live mice. Mol Vis. 2014; 20:163-170

Tan JCH, Francis BA, Noecker R, Uram M, Vakili G, Dustin L, Chopra V. ECP-plus to treat refractory glaucoma, J Glaucoma. 2016 Mar;25(3):e117-22

Francis BA, Pouw A, Jenkins D, Babic K, Vakili G, Tan J, Chopra V, Green RL. Endoscopic Cycloplasty (ECPL) and Lens Extraction in the Treatment of Severe Plateau Iris Syndrome. J Glaucoma. 2016 Mar;25(3):e128-33

Saraswathy S, Tan JC, Yu F, Francis BA, Hinton DR, Weinreb RN, Huang AS. Aqueous Angiography: Real-Time and Physiologic Aqueous Humor Outflow Imaging. PLoS One. 2016;11(1):e0147176. PubMed PMID: 26807586; PubMed Central PMCID: PMC4725949

Gonzalez JM Jr, Ammar MJ, Ko MK, Tan JC. Optimizing two-photon multiple fluorophore imaging of the human trabecular meshwork. Mol Vis. 2016 Mar 2;22:203-12. PubMed PMID: 27122962; PubMed Central PMCID: PMC4835224

Gonzalez JM, Ko MK, Pouw A, Tan JC. Tissue-based multiphoton analysis of actomyosin and structural responses in human trabecular meshwork. Sci Rep. 2016;6:21315. PubMed PMID: 26883567; PubMed Central PMCID: PMC4756353.

Ko MK, Kim EK, Gonzalez JM Jr, Tan JC. Dose- and time-dependent effects of actomyosin inhibition on live mouse outflow resistance and aqueous drainage tissues. Sci Rep. 2016;6:21492. PubMed PMID: 26884319; PubMed Central PMCID: PMC4756686.

Gonzalez JM Jr, Ko MK, Masedunskas A, Hong YK, Weigert R, Tan JC. Toward in vivo two-photon analysis of mouse aqueous outflow structure and function. Exp Eye Res. 2016 May 12. pii: S0014-4835(16)30112-9. doi: 10.1016/j.exer.2016.05.009. [Epub ahead of print] PubMed PMID: 27179411

Huang AS, Saraswathy S, Dastiridou A, Begian A, Mohindroo C, Tan JC, Francis BA, Hinton DR, Weinreb RN. Aqueous Angiography-Mediated Guidance of Trabecular Bypass Improves Angiographic Outflow in Human Enucleated Eyes. Invest Ophthalmol. Vis Sci. 2016 Sep 1;57(11):4558-65. doi: 10.1167/iovs.16-19644. PubMed PMID: 27588614; PubMed Central PMCID: PMC5017267.

Huang A, Saraswathy S, Dastiridou A, Begian A, Legaspi H, Mohindroo C, Tan J, Francis B, Caprioli J, Hinton D, and Weinreb R. Aqueous Angiography With Fluorescein and Indocyanine Green in Bovine Eyes. TVST 2016 Nov 10;5(6):5

Srinivas S, Dastiridou A, Durbin MK, Nittala MG, Huang AA, Tan JC, Francis BA, Sadda SR, Chopra V. Pilot Study of Lamina Cribrosa Intensity Measurements in Glaucoma Using Swept-Source Optical Coherence Tomography. J Glaucoma. 2016 Dec 13. [Epub ahead of print] PubMed PMID: 27977479

Woo R, Akil, H, Olmos de Koo LC, Tan JC. Sustained resolution of macular retinoschisis after trabeculectomy in a patient with progressive glaucoma. J Glaucoma. 2017 Feb 17. doi: 10.1097/IJG.0000000000000632. [Epub ahead of print]

Srinivas S, Dastiridou A, Durbin MK, Nittala MG, Huang AA, Tan JC, Francis BA, Sadda SR, Chopra V. Pilot Study of Lamina Cribrosa Intensity Measurements in Glaucoma Using Swept-Source Optical Coherence Tomography. J Glaucoma. 2017 Feb;26(2):138-143. doi: 10.1097/IJG.0000000000000605

Francis BA, Fernandes RAB, Akil H, Chopra V, Diniz B, Tan J, Huang A. Implantation of a second glaucoma drainage device. Graefes Arch Clin Exp Ophthalmol. 2017 May;255(5):1019-1025. doi: 10.1007/s00417-017-3596-y. Epub 2017 Feb 7. PubMed PMID: 28176011.

Murakami Y, Akil H, Chahal J, Dustin L, Tan J, Chopra V, Francis B. Endoscopic cyclophotocoagulation versus second glaucoma drainage device after prior aqueous tube shunt surgery. Clin Exp Ophthalmol. 2017 Apr;45(3):241-246. doi: 10.1111/ceo.12828. Epub 2016 Oct 2. PubMed PMID: 27570215.

Akil H, Vu PQ, Nguyen AH, Nugent, A, Chopra, V, Francis BA, Tan JC. Reversible Venting Stitch for Fenestrating Valve-less Glaucoma Shunts. J Glaucoma 2017 Dec;26(12):1081-1085. doi: 10.1097/IJG.0000000000000784

Yelenskiy A., Ko M., Chu E., Gonzalez J., Siegmund K., Tan J. Total outflow facility in live C57BL/6 mice of different age. Biomed Hub 2017;2:484126

Gonzalez JM Jr, Ko MK, Hong YK, Weigert R, Tan JC. Deep tissue analysis of distal aqueous drainage structures and contractile features. Sci Rep. 2017 Dec 6;7(1):17071. doi: 10.1038/s41598-017-16897-y

Alizadeh R, Akil H, Tan J, Law SK, Caprioli J. Trabeculectomy Outcomes After Glaucoma Drainage Device Surgery. J Glaucoma. 2018 Feb;27(2):133-139. doi: 10.1097/IJG.0000000000000849. PubMed PMID: 29239864

Yutao Liu, Colleen McDowell, Michael Fautsch, Paul Kaufman, Padmanabhan Pattabiraman, Donald Schwartz, Evan Stubbs, Shan Lin, John Kuchtey, Carol Toris, Alex Huang, Murray Johnstone, John Samples, Mary Wirtz, Ted Acott, Marisse Masis Solano, Vijay Raghunathan, Pedro Gonzalez, Douglas Rhee, Uttio Roy Roy Chowdhury, Paloma Liton, Janice Vranka, Paul Knepper, Paul Russell, Kate Keller, Sanjoy Bhattacharya, Teresa Borras, Thomas Brunner, Sunee Chansangpetch, Abbot Clark, W Michael Dismuke, Yiqin Du, Michael Elliott, Ross Ethier, Jennifer Faralli, Thomas Freddo, Rudolf Fuchshofer, Michael Giovingo, Haiyan Gong, Casey Kopczynski, Thomas Yorio, Elke Lütjen-Drecoll, Markus Kuehn, Raquel Lieberman, Fiona McDonnell, Donna Peters, Mary Kelley, Rachel Kuchtey, Ernst Tamm, James Tan, Karen Torrejon, P Vasanth Rao, Darryl Overby, Daniel Stamer. Concensus Recommendations for Trabecular Meshwork Cell Isolation, Characterization and Culture. Exp Eye Res. 2018;171:164-173

Itakura T, Webster A, Chintala SK, Wang Y, Gonzalez JM Jr, Tan JC, Vranka JA, Acott T, Craft CM, Sibug Saber ME, Jeong S, Stamer WD, Martemyanov KA, Fini ME. GPR158 in the Visual System: Homeostatic Role in Regulation of Intraocular Pressure. J Ocul Pharmacol Ther. 2019 Mar 11. doi: 10.1089/jop.2018.0135.

Wu Y, Seong YJ, Li K, Choi D, Park E, Daghlian GH, Jung E, Bui K, Zhao L, Madhavan S, Daghlian S, Daghlian P, Chin D, Cho IT, Wong AK, Heur M, Zhang-Nunes S, Tan JC, Ema M, Wong TT, Huang AS, Hong YK. Organogenesis and distribution of the ocular lymphatic vessels in the anterior eye. JCI Insight. 2020 Jul 9;5(13):e135121.

Saraswathy S, Bogarin T, Barron E, Francis BA, Tan JCH, Weinreb RN, Huang AS. Segmental differences found in aqueous angiographic-determined high – and low-flow regions of human trabecular meshwork. Exp Eye Res. 2020 Jul;196:108064

Law SK, Salazar D, Yu F, Giaconi JA, Chen A, Chopra V, Francis B, Coleman AL, Lu K, Nouri-Mahdavi K, Tan J, Caprioli J. Efficacy of Combined Suprachoroidal Stent and Cataract Surgery in Patients With Glaucoma. J Glaucoma. 2020 Aug;29(8):627-638.

Johnstone M, Xin C, Tan J, Martin E, Wen J, Wang RK. Aqueous outflow regulation – 21st century concepts. Prog Retin Eye Res. 2021 Jul;83:100917.

Ko MK, Woo JI, Gonzalez JM Jr, Kim G, Sakai L, Peti-Peterdi J, Kelber JA, Hong YK, Tan JC. Fibrillin-1 mutant mouse captures defining features of human primary open glaucoma including anomalous aqueous humor TGF beta-2. Sci Rep. 2022 Jun 23;12(1):10623.

Tan JC, Ko MK, Woo JI, Lu KL, Kelber JA. Aqueous humor TGFβ and fibrillin-1 in Tsk mice reveal clues to POAG pathogenesis. Sci Rep. 2024 Feb 12;14(1):3517

Books

Tan JCH, Associate Editor, Atlas of Clinical Ophthalmology, 3rd Ed. Eds Spalton, Hitchings, Hunter. Elsevier 2005, London, UK. 2005. British Medical Association Best Textbook of the Year; amongst top 5 best-selling ophthalmic textbooks worldwide. Translated into 7 languages.

Francis BA, Sarkisian S, Tan JC; Eds. Minimally Invasive Glaucoma Surgery: Science and Practice. Thieme, 2016: New York.

Book Chapters

Tan JCH, Coroneo MT. Are stretch-activated channels an ocular barometer? In: Mechanotransduction in the Nervous System. Mechanosensitivity in Cells and Tissues Vol 2. Eds, Kamkin A, Kiseleva I, 2008. Springer Verlag; Berlin, p133-144.

Tan JCH, Gabelt BT, Kaufman PL. Changes in aqueous humor dynamics with age and glaucoma. In: Mechanisms and Therapeutics of Glaucoma, Eds Shields B, Tombran-Tink J, Barnstable CJ, 2008. Humana Press, New Jersey; p311-328.

Tan JCH, Kaufman PL, Primary Open Angle Glaucoma. In: Yanoff & Duker’s Ophthalmology, 3rd Edition, 2008. Mosby Elsevier, London, UK; p1154-1158.

Tan JCH and Kaufman PL: Primary Open Angle Glaucoma. In: Yanoff & Duker’s Ophthalmology, 4th Edition, 2014. Mosby Elsevier, London, UK. pp 1052-2056

Francis BA, Sarkisian SR, Tan JC. New Options in the Treatment of Glaucoma. In: Minimally Invasive Glaucoma Surgery: A Practical Guide. Eds: Francis B, Sarkisian S, Tan JC. Thieme, 2016; New York

Akil H, Francis BA, Tan JC, Noecker R. What roles do posterior ciliary processes and pars plana play in aqueous formation? In: Minimally Invasive Glaucoma Surgery: A Practical Guide. Eds: Francis B, Sarkisian S, Tan JC. Thieme, 2016; New York

Tan JCH, Kaufman PL: Primary Open Angle Glaucoma. In: Yanoff & Duker’s Ophthalmology, 5th Edition, Elsevier 2018. p1057

Tan JC, Kaufman PL, Johnstone, M: Primary Open Angle Glaucoma. In: Yanoff & Duker’s Ophthalmology, 6th Edition, Elsevier 2023. p993.

Abstracts

Tan JCH, Lai YK. Characteristics of diabetic retinopathy patients at initial presentation. Malaysia-Singapore Ophthalmic Congress, Kuala Lumpur, May 1995
Tan JCH, Spalton DJ, Arden GB. A comparison of contrast sensitivity tests for posterior capsular opacification. Royal College of Ophthalmologists Annual Congres, Birmingham, May 1997

Tan JCH, Spalton DJ, Arden GB. Measuring glare in posterior capsular opacification. ASCRS, Boston 1997

Tan JCH, Spalton DJ, Arden GB. Comparison of contrast sensitivity tests for the measurement of PCO. ASCRS, Boston, May 1997

Tan JCH, Spalton DJ, Arden GB. Contrast sensitivity testing in PCO. Oxford Congress, June 1997

Tan JCH, Garway-Heath DF, Hitchings RA. Characteristics of the normal peripapillary nerve fibre layer height; ARVO 1999

Tan JCH, Hitchings RA. The effect of IOP reduction on the optic nerve head. Four Professors Glaucoma Symposium. London; November 1999

Westcott MC, Garway-Heath DF, Tan J, Fitzke FW, Hitchings RA. Correlating perimetric sensitivity with structure. The appropriate scaling of differential light sensitivity and the correlation with neuroretinal rim area in glaucoma; ARVO 2000

Tan JCH, Hitchings RA. Effect of non-surgical intraocular pressure reduction on the optic nerve head; ARVO 2000

Poinoosawmy D, Tan J, Hitchings R. The detection of progressive optic disc change in asymmetrical normal pressure glaucoma; ARVO 2000

Neelakanthan A, Tan J, Balidis M, Bunce C, Miller M, Wormald R, Hitchings R. Optic disc characteristics of patients with pigment dispersion syndrome; ARVO 2000

Tan JCH, Hitchings RA. Does improvement ever occur in glaucoma? European Glaucoma Society Congress, London; July 2000

Sharma K, Tan J, Hitchings RA. Sources of variability in three dimensional optic nerve head quantitative analysis; ARVO 2001

Lauande-Pimentel R, Poinoosawmy D, Maino A, Tan J, Garway-Heath DF, Barton K, Hitchings RA. Detection of retinal nerve fibre layer changes in ocular hypertension with scanning laser polarimetry; ARVO 2001

Garway-Heath DF, Tan J, Kamal DS, Hitchings RA. Relative rates of disc and field change in the same eyes at high risk of glaucomatous progression; ARVO 2001

Rai P, Tan J, Hitchings RA. Variability of topographic measurements across regions of the optic nerve head; ARVO 2001

Poinoosawmy D, Tan J, Hitchings RA. Reference plane definition and its influence on optic nerve head rim area measurement; ARVO 2001

Bunce CV, Poinoosawmy D, Tan J, Hitchings RA. Optic disc size and visual field abnormality in glaucoma; ARVO 2001

Tan JCH, Hitchings RA. An approach for detecting glaucoma induced structural change in the optic nerve head; ARVO 2001 [Glaucoma Research Foundation award]

Tan JCH, Hitchings RA. An approach for detecting glaucoma progression at the optic nerve head. European Glaucoma Society closed meeting; Paris, August 2001

Poinoosawmy D, Tan JCH, Garway-Heath DF, Fitzke FW, Hitchings RA. Does change in lens refraction affect the size of images in scanning laser tomography? ARVO 2002

Tan JCH, Poinoosawmy D, Hitchings RA. Progression at the optic nerve head in ocular hypertension and normal pressure glaucoma; ARVO 2002

Tan JCH, Kiland JA, Gabelt BT, Kaufman PL. Orthovanadate alters the cytoskeleton of trabecular meshwork cells and increases outflow facility in live monkeys. ARVO 2006

Lucarelli ML, Tan JCH. Dacryocystocele? Orbital dermoid producing obstruction of lacrimal drainage. American Society of Ophthalmic Plastic and Reconstructive Surgery Spring Scientific Symposium, Key Largo, FL, June 24, 2007

J.M. Gonzalez, Jr., M.C. Edman, S.F. Hamm-Alvarez, J.C.H. Tan. Cellular and Matrix Elements in the Aqueous Outflow Pathway of Human Corneoscleral Transplant Tissue. Invest. Ophthalmol. Vis. Sci. 2010 51: E-Abstract 5776

Gonzalez Jr., JM, Tan JCH. Confocal fluorescence imaging of the trabecular meshwork. Doheny Days Meeting, University of Southern California, Los Angeles, CA. June 11, 2010

Tan JC, Gonzalez Jr, JM, Hamm-Alvarez SJ, Huer M, Song, J. Visualization of Trabecular Meshwork Ultrastructure by In Situ Optical Sectioning. ARVO 2011

Gonzalez Jr, JM, Tan JC. In Situ Imaging and Localization of Trabecular Meshwork Extracellular Matrix Proteins. ARVO 2011

James C. Tan, Ghazal Vakili, Robert Noecker, Brian Francis. “ECP-Plus” to Treat Refractory Glaucoma. American Glaucoma Society, Dana Point, CA, March 2011

Tan, JCH. “ECP-Plus” to Treat Refractory Glaucoma. Doheny Days Conference, Los Angeles, CA, 6/10/11

Tan JC, Gonzalez Jr, JM, Hamm-Alvarez SJ, Huer M, Song, J. Visualization of Trabecular Meshwork Ultrastructure by In Situ Optical Sectioning. Doheny Days Conference, Los Angeles, 6/10/11

Gonzalez Jr, JM, Tan JC. In Situ Imaging and Localization of Trabecular Meshwork Extracellular Matrix Proteins. Doheny Days Conference, Los Angeles, 6/10/11

Tan JCH. In Situ Molecular Imaging of the Human Trabecular Meshwork. Meshwork Society, Denver, CO, December 2011

Tan J, Francis BA, Chopra V, Jenkins D, Pouw A, Babic K. Endoscopic Cilioplasty and Lens Extraction in the Treatment of Severe Plateau Iris Syndrome. American Glaucoma Society 2012

Tan JCH, Gonzalez Jr JM. 3D Analysis Of Actin And Its Disruption In Human Trabecular Meshwork. Gordon Research Conference on Cornea, Biology and Pathobiology, Mar 25-30, 2012

Gonzalez Jr, JM, Tan JCH. Analyzing Live Cellularity in the Human Trabecular Meshwork. Gordon Research Conference on Cornea, Biology and Pathobiology, Mar 25- 30, 2012

Ko MK, Gonzalez Jr, JM, Tan JCH. In Situ Imaging and Localization of Trabecular Meshwork Extracellular Matrix Proteins. Gordon Research Conference on Cornea, Biology and Pathobiology, Mar 25-30, 2012

Le PV, Huang AS, Gonzalez Jr. JM, Tan JC. Image Registration Improves Colocalization Analysis in Two-Photon Microscopy Imaging of the Trabecular Meshwork. ARVO 2012, 3268

Huang AS, Le P, Gonzalez Jr. JM, Tan J. In situ Visualization of Extracellular Matrix Biomarkers in Human Trabecular Meshwork. ARVO 2012

Tan JC, Gonzalez Jr. JM, Hamm-Alvarez SF, Heur M. In Situ 3D Modeling of the Human Trabecular Meshwork. ARVO 2012, 3245

Gonzalez Jr. JM, Tan JC. In Situ 3D Analysis Of Actin And Its Disruption In Human Trabecular Meshwork. ARVO 2012, 2746

Tan JCH. 3D modeling of the human trabecular meshwork. Doheny Days 2012, Los Angeles

Tan JCH. Analyzing Live Cellularity in the Human Trabecular Meshwork. Trabecular Meshwork Society, San Francisco, Dec 15, 2012

Tan JCH. 3D Image Modeling of the Human Trabecular Meshwork. American Glaucoma Society 2013, San Francisco, CA

Ko M, Tan JCH. Voltage-coupled single-needle constant-pressure anterior chamber perfusion in live mice. ARVO 2013

Gonzalez, JM, Tan, JCH. Multimodal Microscopy of Aqueous Drainage Channels in Live Mice. ARVO 2013, Seattle, WA

Tan, JCH, Gonzalez, JM, Ko, M. In situ 3D Distribution of Filamentous Actin in Mouse Trabecular Meshwork. ARVO 2013, Seattle, WA

Hwang J, Gonzalez, JM, Tan, JCH. Live Imaging of Actin Structure in Human Trabecular Meshwork. ARVO 2013, Seattle, WA

Kim EK, Chu E, Tan JCH. Artificial Simulation of Conventional Aqueous Humor Outflow Dynamics. ARVO 2013, Seattle, WA

Tan JCH. 3D Model of Human Trabecular Meshwork and Schlemm’s Canal: Tissue- based drug development. Doheny Days, June 14, 2013, Los Angeles

Tan JCH. Contractile markers distinguish structures of the mouse aqueous drainage tract. Trabecular Meshwork Society, 12/14/2013, New Orleans, Louisiana

Ko M, Kim EK, Tan JCH. Glaucoma drug studies in live mice: effect of latrunculin-B on outflow facility and actomyosin contractility. ARVO 2014, Orlando, FL

Chu ER, Tan JCH. Simulating the effect of trabecular meshwork resistance on conventional aqueous humor outflow dynamics. ARVO 2014, Orlando, FL

Gonzalez JM, Tan JCH. Tissue-based caldesmon silencing by naked siRNA increases F- actin in the human trabecular meshwork. ARVO 2014, Orlando, FL

Kim EK, Tan JCH. Simulating anterior chamber aqueous exchange and drug delivery by single needle perfusion in mice. ARVO 2014, Orlando, FL

Nguyen A, Nugent A, Chopra V, Francis B, Tan JCH. Novel Venting Stitch Technique in Controlling Postoperative Intraocular Pressure in Baerveldt Implants. ARVO 2014, Orlando, FL

Huang AS, Gonzalez J, Medeiros FA, Tan JCH, Rao N, Hinton DR, Weinreb RN. Histological Characterization of Open Angle Glaucomatous Sclera. ARVO 2014, Orlando, FL

Tan JC. Two-photon imaging of the trabecular meshwork. Doheny Days 2014, 6/21/2014, Los Angeles

Murakami Y, Fernandes RAB, Dustin L, Tan JC, Chopra V, Francis BA. Second glaucoma drainage device (GDD-2) versus combined phacoemulsification-GDD-2 after primary tube shunt failure. AAO 2014, Chicago, IL; Abstract ID #30038760

Ko MK, Tan JC. In vivo RhoA activation increases trabecular meshwork contraction and decreases outflow facility. ARVO 5/6/2015, Denver, CO

Tan JC, Gonzalez, JM. Multiphoton excitation parameters for three-color fluorescence imaging of the human trabecular meshwork. ARVO 5/6/2015, Denver, CO

Gonzalez JM, Tan, JC. Mapping abnormal elastin maintenance in the human trabecular meshwork. ARVO 5/6/2015, Denver, CO

Huang AS, Saraswathy S, Francis BA, Hinton DA, Tan JC, Weinreb RN. Aqueous Angiography: A Real-Time, Physiologic, and Comprehensive Aqueous Humor Outflow Imaging Technique. ARVO 5/3/2015, Denver, CO

Tan JC, Gonzalez JM, Ko MK. Contractile elements in the distal aqueous drainage pathway. Nantucket Glaucoma, Aug 27-28, 2015

Tan JC. Evidence for distal drainage tract contractility. Trabecular Meshwork Society. San Diego, CA. Dec 12, 2015

Tan JC. Contractility of aqueous humor drainage. Caltech Ophthalmic Engineering Meeting, Pasadena, May 12, 2016

Saraswathy S, Dastiridou A, Begian A, Legaspi H, Tan JC, Francis B, Hinton DR, Weinreb RN, Huang AS. Trabecular Micro-Bypass Stent Placement Influences Aqueous Angiography-Visualized Aqueous Humor Outflow in Human Eyes, ARVO 2016, 4699-D0184

Tan JC. MIGS and the aqueous outlow pump. Doheny-UCLA bioengineering joint meeting, Westwood, June 9, 2016

Alex S. Huang, Sindhu Saraswathy, Anna Dastiridou, Alan Begian, Hanz Legaspi, James Tan, Brian A. Francis, David R. Hinton, and Robert N. Weinreb. Aqueous Angiography: Real-Time Imaging of Aqueous Humor Outflow. ARVO ISIE, 2016

Tan, JC. Contractility of distal aqueous outflow. International Society of Eye Research (ISER), Tokyo, Japan, September 2016

Tan JC. Contractility of aqueous humor drainage: focus on the distal tract. International Glaucoma Symposium, Los Angeles, Nov 5, 2016.

Tan JC. Glaucoma features in a fibrillin-1 mutant mouse. Trabecular Meshwork Study Club, San Francisco, Dec 3, 2016

Tan JC. Contractility of aqueous humor drainage in the distal tract. Stein-Doheny Glaucoma Retreat. Westwood, CA, Feb 17, 2017

Tan J, Gonzalez, J Jr, Ko M, Weigert R, Hong Y. Contractile Capacity of the Distal Aqueous Drainage System.American Glaucoma Society, San Diego, 3/4/2017, Abstract book p301

Alizadeh, R, Akil H, Tan J, Caprioli J, Law S. Trabeculectomy Success Rate After Glaucoma Drainage Device Surgery American Glaucoma Society, San Diego, 3/4/2017, Abstract book p141

Saraswathy S, Bogarin T, Mohindroo C, Francis BA, Tan JC, Hinton DR, Weinreb RN, Huang AS. Aqueous Angiography Based Comparison of High- and Low-Flow Regions for Alpha-Smooth Muscle Actin (α-SMA) and Versican in Post-Mortem Human Eyes. ARVO 2017, Baltimore, MD. Abstract #3479

Tan JC, Gonzalez J, Ko MK, Masedunskas A, Weigert R, Hong Y. Contractile features of the distal aqueous drainage tract. ARVO 2017, Baltimore, MD. Abstract #3771

Ko MK, Gonzalez JM, Tan JC. Glaucoma features in a fibrillin-1 mutant mouse. ARVO 2017, Baltimore, MD. Abstract #2556

Bogarin T, Saraswathy S, Tannous E, Zhang C, Gonzalez J, Tan JC, Hinton DR, Weinreb RN, Zheng JJ, Huang AS. Steroid-Response in Primary Culture Scleral Cells, Implications for Distal Outflow Pathology. ARVO 2017, Baltimore, MD. Abstract #3480

Alizadeh R, Akil H, Tan JC, Law SK, Caprioli J. Trabeculectomy can be Successful after Glaucoma Drainage Device surgery. ARVO 2017, Baltimore, MD. Abstract #4971

Tan, JC. A half-century of trabeculectomy and some new subconjunctival drainage surgeries. International Glaucoma Symposium, Los Angeles, Nov 5, 2017.

Tan, J. Mouse IOP and human POAG: a clinical perspective. Trabecular Meshwork Society, Portland, OR. Dec 1, 2017

Tan JC. Proposal for a mouse model mimicking POAG. 3rd UCLA Stein-Doheny Glaucoma Symposium. Westwood, Feb 2, 2018.

Itakura T, Webster A, Gonzalez, Jr. JM, Tan JCH, Craft CM, Vranka JA, Keller KE, Acott T, Stamer WD, Martemyanov K, Fini EM. Homeostatic role for GPR158 in modulation of intraocular pressure (IOP). ARVO; May 2, 2018

Tan JC. Modification of valve-less tubes to reliably control early post-operative IOP. Stein Eye Institute Glaucoma Meeting, Westwood. May 23, 2018

Tan JC. Proposal for a mouse model of POAG. SEI-DEI Joint Research Retreat, Westwood. Feb 2, 2018

Tan JC. Further observations of a fibrillin-1 mutant mouse and relevance to POAG. Trabecular Meshwork Society. San Diego, CA, Dec 8, 2018.

Ko, MK, Woo, J, Gonzalez J, Kim G, Tan JC. Fibrillin-1 mutant mouse mimics abnormal aqueous humor TGFβ2 and phenotype of human POAG. ARVO, Vancouver, Canada, May 2, 2019

Internet publications

Tan JCH, Non-Penetrating Glaucoma Surgery. In: Wells T, Ed. EyeText.net, Internet Textbook of Ophthalmology. London, UK; 2001

Tan JCH, Winarko J. Review of: Late needling of flat filtering blebs with adjunctive mitomycin C: efficacy and safety for the corneal endothelium. (Ophthalmology Apr 2011). Faculty of 1000; f1000.com

Huang A, Tan JCH. Review of: Long-term development of significant visual field defects in highly myopic eyes. 2012. Ohno-Matsui K, Shimada N, Yasuzumi K, et al. Am J Ophthalmol. 2011 Aug; 152(2):256-265.e1. Faculty of 1000; f1000.com

Huang A, Tan JCH. Review of: Sustained elevation of intraocular pressure after intravitreal injections of anti-VEGF agents. 2012. Good TJ, Kimura AE, Mandava N, Kahook MY. Br. J Ophthalmol. 2011 Aug; 95(8):1111-4. Faculty of 1000; f1000.com

Tan JCH, Huang A. Review of Prophylactic selective laser trabeculoplasty in the prevention of intraocular pressure elevation after intravitreal triamcinolone acetonide injection. 2012. E Bozkurt, N Kara, AT Yazici,K Yuksel,A Demirok,OF Yilmaz,S Demir. Am J Ophthalmol 2011,152,6. Faculty of 1000; f1000.com

Tan JCH, Huang A. Long-term results of primary trabeculectomies and Molteno implants for primary open-angle glaucoma. 2012. AC Molteno, TH Bevin, P Herbison, MA Husni. Arch Ophthalmol 2011,129,11. Faculty of 1000; f1000.com

Tan JCH. International Glaucoma Review. Editorial invitation to comment on: Direct trabecular meshwork imaging in porcine eyes through multiphoton gonioscopy; Masihzadeh O, Ammar DA, Kahook MY, Gibson EA, Lei TC. Journal of Biomedical Optics 2013; 18: 036009

Tan JCH. International Glaucoma Review. Editorial invitation to comment on: Substratum stiffness and latrunculin B modulate the gene expression of the mechanotransducers YAP and TAZ in human trabecular meshwork cells. Thomasy SM, Morgan JT, Wood JA, Murphy CJ, Russell P. Exp Eye Res 2013; 113: 66-7310.

Tan JCH. Glaucoma Today, Jan 2014. Editorial invitation to comment on: Malihi M, Filho ERM, Hodge DO, Sit AJ. Long-Term Trends in Glaucoma-Related Blindness in Olmsted County, Minnesota. Am J Ophthalmol 2013;156:724–73

Tan JCH. Glaucoma Today, Jan 2014. Editorial invitation to comment on: Peters D, Bengtsson B, Heijl A. Lifetime risk of blindness in open-angle glaucoma. Am J Ophthalmol. 2013 Oct;156(4):724-30